Normally, cortisol levels increase through a chain reaction of hormones. The brain's hypothalamus produces corticotropin-releasing hormone (CRH), which stimulates the pituitary gland to make adrenocorticotropic hormone (ACTH). Then, ACTH stimulates the adrenal glands to produce cortisol.
Cortisol affects almost every area of the body and is particularly important in regulating blood pressure and metabolism.
But if your body makes too much cortisol—or if you take certain medications that act like cortisol—you may develop a variety of symptoms. Cushing's syndrome may cause weight gain, skin changes, and fatigue and lead to such serious conditions as diabetes, high blood pressure, depression, and osteoporosis. If untreated, Cushing's syndrome can cause death.
another pictures of cushing disease:1. Hairy face(hirsutism)